Selective Hydrogenation of Halogenated Nitroaromatics to Haloanilines in Batch and Flow

P Loos, H Alex, J Hassfeld, K Lovis…

Index: Chen, Mao; Buchwald, Stephen L. Angewandte Chemie - International Edition, 2013 , vol. 52, # 15 p. 4247 - 4250 Angew. Chem., 2013 , vol. 125, # 15 p. 4341 - 4344,4

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Abstract

... Volume: Page: ... Using 15 mol % Raney Co at 5 bar H 2 , 80 °C resulted in only 2% conversion after 4 h. Pt–V/C and Raney ... temperature, the model substrate 1-iodo-4-nitrobenzene 1a was soluble in THF in concentrations of approximately 0.6 M (149 g/L; in the ...