Tetrahedron

Palladium-catalyzed oxidative alkynylation of arene C–H bond using the chelation-assisted strategy

SH Kim, SH Park, S Chang

Index: Kim, Seok Hwan; Park, Sae Hume; Chang, Sukbok Tetrahedron, 2012 , vol. 68, # 26 p. 5162 - 5166

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Citation Number: 44

Abstract

Palladium-catalyzed alkynylation of arene C–H bonds with (triisopropylsilyl) acetylene was developed for the first time under oxidative conditions in the present study. Among various type of directing groups examined, the N-phenyl-2-aminopyridine skeleton was shown to be most effective and selective for the Pd-catalyzed direct alkynylation reaction, and the desired alkynylated products were obtained in moderate to good yields.

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