Antimicrobial activity of amino acid, imidazole, and sulfonamide derivatives of pyrazolo [3, 4??d] pyrimidine

MM Ghorab, ZH Ismail, SM Abdel??Gawad…

Index: Ghorab; Ismail, Zeinab H.; Abdel-Gawad, Soad M.; Aziem, Anhar Abdel Heteroatom Chemistry, 2004 , vol. 15, # 1 p. 57 - 62

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Citation Number: 75

Abstract

Abstract Derivatives of pyrazolo [3, 4-d] pyrimidine with amino acid 3a–d, imidazole 4a–d, carbonyl 6–9, pyrazole 10, pyrazolone 11, and sulfonamide 12–17 moieties were synthesized. Structure of the new compounds were established by their elemental analyses and spectral data. Some of the synthesized compounds were tested in vitro for their antimicrobial activity. Compounds 4b, 12, and 16 were almost as potent as the standard ...