Antimicrobial activity of fluorinated 1, 2-benzisothiazol-3 (2H)-ones and 2, 2′-dithiobis (benzamides)

…, G Pagani, M Pregnolato, M Terreni, F Pastoni

Index: Carmellino; Pagani; Pregnolato; Terreni; Pastoni European Journal of Medicinal Chemistry, 1994 , vol. 29, # 10 p. 743 - 751

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Citation Number: 18

Abstract

Abstract Fluoro and trifluoromethyl derivatives of 1, 2-benzisothiazol-3 (2H)-ones and the 2, 2′-dithiobis (benzamides) have been prepared and their antifungal and antibacterial activity evaluated. Several compounds were found highly active against fungi and Gram- positive microorganisms and a few derivatives displayed some activity against Gram- negative strains. Structure-activity relationships are proposed.