A straightforward and efficient method for the synthesis of diversely substituted β-aminoketones and γ-aminoalcohols from 3-(N, N-dimethylamino) …

…, D Arteaga, J Castillo, B Insuasty, J Quiroga…

Index: Abonia, Rodrigo; Arteaga, Danny; Castillo, Juan; Insuasty, Braulio; Quiroga, Jairo; Ortiz, Alejandro Journal of the Brazilian Chemical Society, 2013 , vol. 24, # 9 p. 1396 - 1402

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Citation Number: 4

Abstract

ABSTRACT Libraries of novel β-aminoketones and γ-aminoalcohols showing a wide structural diversity were easily obtained from a simple approach, using 3-(N, N- dimethylamino) propiophenone derivatives as key starting material. The procedure involved initially an N-alkylation of secondary benzylamines with propiophenone salts yielding the desired β-aminoketones. Chemical or catalytic reduction of their carbonyl groups provided ...

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