Derivatives of 8-hydroxy-2-methylquinoline are powerful prototypes for zinc sensors in biological systems

…, N Jotterand, IS Carrico, B Imperiali

Index: Pearce; Jotterand; Carrico; Imperiali Journal of the American Chemical Society, 2001 , vol. 123, # 21 p. 5160 - 5161

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Citation Number: 192

Abstract

The recent emphasis on understanding the myriad roles of zinc in both normal and diseased cells and tissues1 has placed an ever increasing demand on methods for sensitive and selective methods for real-time monitoring of free Zn2+ in complex biological samples. Chelation-enhanced fluorescent sensors for zinc, based on fluorophores such as quinoline, 2 dansyl, 3 fluorescein, 4 and anthracene, 5 have been reported. While each of these ...