Structure–activity studies on the anti-proliferation activity of ajoene analogues in WHCO1 oesophageal cancer cells

…, T Ogunleye, P Richards, J Cotton, K Zilbeyaz…

Index: Kaschula, Catherine H.; Hunter, Roger; Stellenboom, Nashia; Caira, Mino R.; Winks, Susan; Ogunleye, Thozama; Richards, Philip; Cotton, Jonathan; Zilbeyaz, Kani; Wang, Yabing; Siyo, Vuyolwethu; Ngarande, Ellen; Parker, M. Iqbal European Journal of Medicinal Chemistry, 2012 , vol. 50, p. 236 - 254

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Citation Number: 23

Abstract

The organosulfur compound ajoene derived from the rearrangement of allicin found in crushed garlic can inhibit the proliferation of tumour cells by inducing G2/M cell cycle arrest and apoptosis. We report on the application of a concise four-step synthesis (Hunter et al., 2008 [1]) that allows access to ajoene analogues with the end allyl groups substituted. A library of twelve such derivatives tested for their anti-proliferation activity against WHCO1 ...

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