Cytotoxic 2′, 5′-dihydroxychalcones with unexpected antiangiogenic activity

NH Nam, Y Kim, YJ You, DH Hong, HM Kim…

Index: Nam, Nguyen-Hai; Kim, Yong; You, Young-Jae; Hong, Dong-Ho; Kim, Hwan-Mook; Ahn, Byung-Zun European journal of medicinal chemistry, 2003 , vol. 38, # 2 p. 179 - 187

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Citation Number: 90

Abstract

A series of 2′, 5′-dihydroxychalcones were synthesized and evaluated for cytotoxicity against tumor cell lines and human umbilical venous endothelial cells (HUVEC). It was found that chalcones with electron-withdrawing substituents on the B ring exhibited potent cytotoxicity against a variety of tumor cell lines while compounds with electron-releasing groups were less potent in general. Those compounds with B ring replaced by extended ...