p-Cyano substituted benzophenone as an excellent photophore for one-electron oxidation of DNA

K Nakatani, C Dohno, T Nakamura, I Saito

Index: Nakatani, Kazuhiko; Dohno, Chikara; Nakamura, Takashi; Saito, Isao Tetrahedron Letters, 1998 , vol. 39, # 18 p. 2779 - 2782

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Citation Number: 28

Abstract

Novel DNA-photocleaving molecule 1 consisting of a p-cyano substituted benzophenone photophore and an alkyl amino side chain was developed. DNA cleavage by 1 under photoirradiation conditions occurred selectively at 5′ side G of 5′ GG3′ sequence after hot piperidine treatment. Photoirradiation of deoxyguanosine at 312 nm in the presence of 1 efficiently produced imidazolone as a predominant product.