Metalation of t??butyl sulfoxides, sulfones and sulfonamides of pyridazine and pyrazine. Metalation of diazines. XX

…, N Plé, P Pollet, G Quéguiner

Index: Turck, Alain; Ple, Nelly; Pollet, Pamela; Queguiner, Guy Journal of Heterocyclic Chemistry, 1998 , vol. 35, # 2 p. 429 - 436

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Citation Number: 17

Abstract

Abstract In the pyridazine series, the use of tert-butylsulfinyl and tert-butylsulfonyl as ortho directing groups for metalation has been tested. Various functionalized products were obtained in good yields. In the case of 3-tert-butylsulfinyl-6-methoxypyridazine, the metalation was regioselective in ortho to the sulfinyl group. The metalation of 2-tert- butylsulfinyl and 2-tert-butylsulfonylpyrazine gave low to moderate yields. Synthesis of ...