Tetrahedron letters

Synthesis of fluorinated α-amino ketones. Part II: α-acylaminoalkyl α′, α′-difluoroalkyl ketones

M Kolb, B Neises

Index: Kolb, Michael; Neises, Bernhard Tetrahedron Letters, 1986 ,  vol. 27,  # 37  p. 4437 - 4440

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Citation Number: 29

Abstract

The synthesis of α-acylaminoalkyl 1.1-difluoro-3-butenyl ketones is described. Reaction of substituted 5(4H)-oxazolones , obtained from α-amino acids, with 2.2-difluoro-4-pentenoic acid anhydride (for R 2 = C 6 H 5 ) or with 2.2-difluoro-4-pentenoic acid chloride and 4- ...