The Journal of Organic Chemistry

Fluorinated Aromatic Amino Acids. I. o-, m-, and p-Trifluoromethylphenylalanines1

R FILLER, H NOVAR

Index: Filler,R.; Novar,H. Journal of Organic Chemistry, 1960 ,  vol. 25, p. 733 - 736            

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Citation Number: 15

Abstract

The preparation of m-trifluoromethylbenzalde-hyde from the bromo Grignard reagent and N- methylformanilide has been described. l3 Our yield of 38y0 of pure aldehyde however, was considerably lower than the 52--59y0 previously reported. 13 It should be mentioned that autoxidation of this aldehyde to m-trifluoromethylbenzoic acid occurred within several hours at room temperature, so that the reaction with aceturic acid to form 2-methyl-4-(m- ...