Synthesis, cytotoxicity, and antiviral activity of some acyclic analogs of the pyrrolo [2, 3-d] pyrimidine nucleoside antibiotics tubercidin, toyocamycin, and sangivamycin

…, LL Wotring, JC Drach, LB Townsend

Index: Gupta, Pranab K.; Daunert, Sylvia; Nassiri, M. Reza; Wotring, Linda L.; Drach, John C.; Townsend, Leroy B. Journal of Medicinal Chemistry, 1989 ,  vol. 32,  # 2  p. 402 - 408

Full Text: HTML

Citation Number: 64

Abstract

The observation that some pyrrolo [2, 3-d] pyrimidine nucleosides, but not others, possess antiviral activity led us to initiate the synthesis of (dihydroxypropoxy) methyl (DHPG-like) analogues of toyocamycin, tubercidin, and sangivamycin. The antiherpes activity of other acyclic nucleosides such as 2', 3'-secoguanosine and (R, S)-9-[1-(2-hydroxyet hoxy)-2- hydroxyethyl] guanine2'also prompted us to prepare the seco nucleosides of tubercidin, ...