Phenanthrylalkanoic Acids, III: Syntheses and Biological Activities of 4??Phenanthryl Derivatives

A Eirín, F Fernández, G Gómez, C López…

Index: Eirin; Fernandez; Gomez; Lopez; Santos; Calleja; Cano Archiv der Pharmazie, 1989 ,  vol. 322,  # 5  p. 281 - 284

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Citation Number: 2

Abstract

Abstract Reformatsky reactions between 2, 3-dihydro-4 (1H)-phenanthrenone (5) and ethyl α- bromoacetate or propanoate yield several unsaturated esters which, upon aromatization followed by saponification, lead to the 4-phenanthrylacetic (1) and 2-(4-phenanthryl) propanoic (2) acids. The analgesic and antiinflammatory properties of 1 and 2 were measured and compared with those of Fenbufen.