Synthesis

Tin (IV) chloride-sodium nitrite as a new nitrosating agent for N-nitrosation of amines, amides and ureas under mild and heterogeneous conditions

B Celaries, C Parkanyi

Index: Celaries, Benoit; Parkanyi, Cyril Synthesis, 2006 , # 14 p. 2371 - 2375

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Citation Number: 6

Abstract

Abstract We have developed a new method of N-nitrosation of various secondary and tertiary amines, amides and ureas using a mixture of tin (IV) chloride and sodium nitrate. This method leads to a selective, high-yielding and mild heterogeneous N-nitrosation by in situ generation of nitrosyl chloride (NOCl). The reaction can be carried out in several different solvents such as chloroform, dichloromethane, ethers, ethyl acetate and alcohols, ...

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