Multi-substituted heterocycles

H Benmansour, RD Chambers, PR Hoskin…

Index: Benmansour; Chambers; Hoskin; Sandford Journal of Fluorine Chemistry, 2001 , vol. 112, # 1 p. 133 - 137

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Citation Number: 18

Abstract

Pentafluoropyridine was used as the starting material for the preparation of a range of pyridine derivatives that bear five different substituents. In this context, syntheses of penta- functional pyridine systems by sequences of nucleophilic aromatic substitution, palladium catalysed coupling and bromo-lithiation processes are described.