An Efficient Semi??Synthetic Method to Construct Docetaxel via Sterically Crowded Linear Side Chain Esterification

X Shen, J Yang, H Zhan, H Wang…

Index: Shen, Xin; Yang, Jidong; Zhan, Huaxing; Wang, Hu; Wu, Shaohong; Chen, Zili Chinese Journal of Chemistry, 2013 , vol. 31, # 1 p. 31 - 36

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Abstract

Abstract An efficient semi-synthetic method was developed to construct docetaxel 1 by using N, N-di-Boc protected linear isoserine derivative 5 as the side chain source, in which, bulky protecting group on the nitrogen atom blocked C-2′ position and prohibited unavoidable racemization in previous studies.