The Journal of Organic Chemistry

A new and simple synthesis of Mosher's acid

Y Goldberg, H Alper

Index: Goldberg, Yuri; Alper, Howard Journal of Organic Chemistry, 1992 , vol. 57, # 13 p. 3731 - 3732

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Citation Number: 10

Abstract

A frequently used chiral reagent for the determination of enantiomeric purity of chiral alcohols and amines' is a-methoxy-a-(trifluoromethy1) phenylacetic acid, also known as Mosher's acida2 This compound has been syn-thesized by reaction of a, a, a- trifluoroacetophenone (1) with sodium cyanide in 1, Zdimethoxyethane (DME) followed by alkylation with dimethyl sulfate to give the nitrile 2 and finally hydrolysis of%,, first to the ...

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