Design, synthesis, and biological activities of cyclic lactam peptide analogues of Dynorphin A (1-11)-NH2 1

FDT Lung, N Collins, D Stropova, P Davis…

Index: Lung; Collins; Stropova; Davis; Yamamura; Porreca; Hruby Journal of Medicinal Chemistry, 1996 , vol. 39, # 5 p. 1136 - 1141

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Citation Number: 28

Abstract

We previously have reported four possible binding conformations of dynorphin A (Dyn A) for the central κ opioid receptors, induced by the address sequence, using a molecular mechanics energy minimization approach. The lowest energy conformation was found to exhibit an α-helical conformation in the cyclized address sequence. It was suggested that an α-helical conformation in the cyclized address sequence or a helical conformation ...

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