Preparation of 3-bromo-l-tyrosine and 3, 5-dibromo-l-tyrosine

RS Phillips, S Busby, L Edenfield, K Wickware

Index: Phillips, Robert S.; Busby, Susan; Edenfield, Leia; Wickware, Kevin Amino Acids, 2013 , vol. 44, # 2 p. 529 - 532

Full Text: HTML

Citation Number: 2

Abstract

Abstract l-Tyrosine is converted to 3-bromo-l-tyrosine in good yield by reaction with 1.2 equiv. of DMSO in HBr/AcOH, while reaction with 2.2 equiv. of DMSO under comparable conditions results in formation of 3, 5-dibromo-l-tyrosine in good yield. This is the simplest, safest and most efficient method for the preparation of gram quantities of either 3-bromo-l- tyrosine or 3, 5-dibromo-l-tyrosine.