The first general method for α-trifluoromethylation of carboxylic acids using BrF3

A Hagooly, S Rozen

Index: Hagooly, Aviv; Rozen, Shlomo Chemical Communications, 2004 , # 5 p. 594 - 595

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Citation Number: 9

Abstract

Still, only a few, highly specific α-trifluoromethyl carboxylates have been described so far. Recent examples include constructing α-alkoxy-α-trifluoromethyl acids 3 and a procedure for electrophilic trifluoromethylation of the strongly nucleophilic carbon of β-ketocarboxylates. 4 Attempting α-alkylation of β,β,β- trifluoropropionates was proven impractical since a facile defluorination takes place even at −78 ░C: (CF 3 CH 2 COOR + B − → CF 2 CHCOOR). 5 Clearly, a ...