Synthesis, activity, and molecular modeling studies of novel human aldose reductase inhibitors based on a marine natural product

JÁ de la Fuente, S Manzanaro, MJ Martín…

Index: Cullinane; Davey; Padfield Journal of the Chemical Society, 1934 , p. 716,719

Full Text: HTML

Citation Number: 47

Abstract

... Journal of Medicinal Chemistry. ... 5,9-11 The most potent and better characterized orally active ARIs belong to two main chemical classes: (i) carboxylic acid derivatives, such as tolrestat, zopolrestat, and zenarestat, and (ii) spiro-hydantoins, such as sorbinil (Figure 1). ...

Related Articles:

Nitrations and oxidations with inorganic nitrate salts in trifluoroacetic anhydride

[Crivello, J.V. Journal of Organic Chemistry, 1981 , vol. 46, # 15 p. 3056 - 3060]

Thermolyse des carbonates d'aryle initee par les bases: I-mecanisme par SNAr dans le cas des carbonates d'aryle porteurs de groupes electro-attracteurs identiques.

[Jost, Philippe; Forestiere, Alain; Sillion, Bernard; Le Perchec, Pierre Tetrahedron Letters, 1982 , vol. 23, # 42 p. 4311 - 4314]

Preparation of Some Bis (nitrophenyl) Ethers, Bis (aminophenyl) Ethers, and Some Derived Azo Compounds1

[Randall,J.J. et al. Journal of Organic Chemistry, 1962 , vol. 27, p. 4098 - 4101]

Phosphorus-nitrogen compounds. 25. Substituent exchange and carbon-oxygen bond cleavage with aryloxycyclophosphazenes

[Allcock,H.R.; Smeltz,L.A. Journal of the American Chemical Society, 1976 , vol. 98, p. 4143 - 4149]

Studies on furan derivatives. XII. Nucleophilic substitution of methyl 5??nitro??2??furancarboxylate. Preparation of methyl 5??phenoxy??2??furancarboxylates

[Tanaka, Akira; Usui, Toshinao; Shimadzu, Masaji Journal of Heterocyclic Chemistry, 1981 , vol. 18, p. 1241 - 1244]

More Articles...