Synthesis

An Efficient Procedure for the Synthesis of 5H-6-Substituted-pyrazolo [1, 5-d]-1, 2, 4-triazine-4, 7-diones

PG Baraldi, B Cacciari, R Romagnoli, G Spalluto

Index: Baraldi, Pier Giovanni; Cacciari, Barbara; Romagnoli, Romeo; Spalluto, Giampiero Synthesis, 1999 , # 3 p. 453 - 458

Full Text: HTML

Citation Number: 5

Abstract

Abstract: A new series of 5, 6-dihydropyrazolo [1, 5-d]-1, 2, 4-triazine-4, 7-diones substituted in the 6-position with various phenyl substituents has been synthesized and found to have activity, owing to their acylating properties, as inhibitors of the serine protease enzymes. Key words: dioxopiperazine, 5-pyrazolecarboxhydrazides cyclization, trichloromethyl chloroformate, protease inhibitors