Organic & biomolecular chemistry

Synthesis of (R)-2-methyl-4-deoxy and (R)-2-methyl-4, 5-dideoxy analogues of 6-phosphogluconate as potential inhibitors of 6-phosphogluconate dehydrogenase

C Dardonville, IH Gilbert

Index: Organic and biomolecular chemistry, , vol. 1, # 3 p. 552 - 559

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Citation Number: 7

Abstract

... High-resolution mass spectra (HRMS) in chemical ionisation (CI) and fast atom bombardment (FAB) were ... The organic phase was dried (MgSO 4 ) and concentrated to give a crude yellow ... Chromatography with EtOAc–hexane (3 ∶ 1) afforded the pure ester 5 as a colourless oil ...

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