Synthetic Communications

Synthesis of dye-labeled lysine derivatives

Z Shen, Y Zhang, Y Chen

Index: Shen, Zongxuan; Zhang, Yawen; Chen, Yan Synthetic Communications, 2000 , vol. 30, # 14 p. 2525 - 2532

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Citation Number: 6

Abstract

Abstract The N′-dabcyl-N α-(9-fluorenylmethoxy)-carbonyllysine was prepared by reaction of lysine-Cu2+ complex with the N-hydroxysuccinimide (HOSu) activated ester of [4-(4'- dimethylamino) phenylazo] benzoic acid (dabcyl acid) followed by treatment with EDTA and acylation with Fmoc-OSu, and the N α-tert-butyloxycarbonyl-N′-dabcyllysine was prepared by reaction of N α-tert-butyloxycarbonyllysine with dabcyl-OSu.