Discovery of Potent, Selective, and Orally Active Carboxylic Acid Based Inhibitors of Matrix Metalloproteinase-13†

LG Monovich, RA Tommasi, RA Fujimoto…

Index: Journal of Medicinal Chemistry, , vol. 52, # 11 p. 3523 - 3538

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Citation Number: 39

Abstract

... Journal of Medicinal Chemistry. ... Efforts within the pharmaceutical industry to target MMPs as a therapeutic approach initially used broad-based hydroxamic acid inhibitors 1, 4(10) (cipemastat), 5(11) (marimastat), and 6(12) (AG3340). ...