Xenobiotica

Metabolism of 2, 3, 5, 6-tetrachloronitrobenzene (tecnazene) in rat

GJ Lappin, D Pritchard, RB Moore, WJD Laird

Index: Lappin; Pritchard; Moore; Laird Xenobiotica, 1996 , vol. 26, # 1 p. 65 - 77

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Citation Number: 3

Abstract

1. The metabolic fate of [U-14C]-2, 3, 5, 6-tetrachloronitrobenzene (tecnazene) has been determined in the male and female rat following a single dose of 1 mg/kg and in surgically prepared, bile-duct-cannulated rats following a single oral dose of 135 mg/kg. 2. Radioactivity in the female rat was excreted mainly in urine (82%). The male rat, however, excreted approximately equal amounts of radioactivity in urine and faeces (the latter via ...