Synthesis, antiproliferative, and vasorelaxing evaluations of coumarin α-methylene-γ-butyrolactones

…, SJ Lee, DH Kuo, IL Chen, TC Wang, CC Tzeng

Index: Chen, Yeh-Long; Lu, Chih-Ming; Lee, Shoiw-Ju; Kuo, Daih-Huang; Chen, I-Li; Wang, Tai-Chi; Tzeng, Cherng-Chyi Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 20 p. 5710 - 5716

Full Text: HTML

Citation Number: 30

Abstract

Certain coumarin α-methylene-γ-butyrolactones were synthesized and evaluated for antiproliferative and vasorelaxing activities. These compounds were synthesized via alkylation of hydroxycoumarins 2a–f followed by oxidation and the Reformatsky-type condensation. The results of this study are as follows (1) for the vasorelaxing activity, coumarin-7-yl α-methylene-γ-butyrolactone 6d, with an IC50 value of 9.4 μM against pig ...