DNA duplexes stabilized by modified monomer residues: synthesis and stability

JA Parkinson

Index: Graham, Duncan; Parkinson, John A.; Brown, Tom Journal of the Chemical Society - Perkin Transactions 1, 1998 , # 6 p. 1131 - 1138

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Citation Number: 78

Abstract

The synthesis of a series of 2′-deoxyuridine analogues modified at the 5-position and a series of 2′-deoxypurines modified at the 8-position is described. Ultraviolet melting studies have been used to assess the stability of DNA duplexes 12-and 8-residues in length that contain these modifications. Of those modified residues which have been incorporated into oligonucleotides, 5-(prop-1-ynyl)-2′-deoxyuridine is found to impart the greatest ...