Mannich bases of 3H-pyrrolo [3, 2-f] quinoline having vasorelaxing activity

…, G Chiarelotto, F Antonucci, L Caparrotta…

Index: Ferlin, Maria Grazia; Chiarelotto, Gianfranco; Antonucci, Francesca; Caparrotta, Laura; Froldi, Guglielmina European Journal of Medicinal Chemistry, 2002 , vol. 37, # 5 p. 427 - 434

Full Text: HTML

Citation Number: 48

Abstract

Mannich bases obtained by aminoalkylation of 3H-pyrrolo [3, 2-f] quinoline were designed and prepared as potential vasorelaxing agents. Compounds Ia–Va were characterised by IR, 1H-NMR, mass spectral data and elemental analysis; IIb, c–Vb, c were also confirmed by 1H-NMR spectra of reaction mixtures. To estimate their vascular activity, prototypes 1-(N, N- dimethylaminomethyl)-(Ia) and 1-(4-phenyl-piperazin-1-ylmethyl)-(IVa) 3H-pyrrolo [3, 2-f] ...

Related Articles:

An expeditious synthesis of cytotoxic pyrroloisoquinoline derivatives.: Structure–activity comparative studies with isomeric pyrroloquinolines

[Vlachou, Margarita; Tsotinis, Andrew; Kelland, Lloyd R.; Thurston, David E. Heterocycles, 2002 , vol. 57, # 1 p. 129 - 133]

An expeditious synthesis of cytotoxic pyrroloisoquinoline derivatives.: Structure–activity comparative studies with isomeric pyrroloquinolines

[Vlachou, Margarita; Tsotinis, Andrew; Kelland, Lloyd R.; Thurston, David E. Heterocycles, 2002 , vol. 57, # 1 p. 129 - 133]

Vielzähnige nichtcyclische Neutralliganden und ihre Komplexierung

[Wieland; Horner Justus Liebigs Annalen der Chemie, 1938 , vol. 536, p. 89,95]

More Articles...