Zinc??Catalyzed Amide Cleavage and Esterification of β??Hydroxyethylamides

…, Y Nishii, T Higuchi, K Mashima

Index: Kita, Yusuke; Nishii, Yuji; Higuchi, Takafumi; Mashima, Kazushi Angewandte Chemie - International Edition, 2012 , vol. 51, # 23 p. 5723 - 5726

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Citation Number: 27

Abstract

Amides are ubiquitous in nature and have extremely stable bonds, as their half-life for spontaneous hydrolysis is estimated to be 350 to 600years at neutral pH and room temperature.[1] In the biological metabolic cycle in nature, in contrast to the relatively easy formation of amides, the cleavage (hydrolysis) of amide bonds is an energy-consuming, ATP- dependent event that requires enzymes.[2] In chemical evolution in the pre-enzyme era, ...