Synthesis of α-N-Ethylamino Acids and their Derivatives

H Schedel, K Burger

Index: Schedel, Hartmut; Burger, Klaus Monatshefte fur Chemie, 2000 , vol. 131, # 9 p. 1011 - 1018

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Citation Number: 7

Abstract

Summary. A new synthesis of α-N-ethylamino acids starting from α-amino acids using hexafluoroacetone as protecting and activating agent is described. The hexafluoroacetone- protected N-ethylamino acid derivatives obtained are activated lactons. Therefore, they can be directly transformed without the need of an additional activation step with various nucleophiles into the corresponding carboxylic acid derivatives.