Discovery of dual target inhibitors against cyclooxygenases and leukotriene A4 hydrolyase

Z Chen, Y Wu, Y Liu, S Yang, Y Chen…

Index: Chen, Zheng; Wu, Yiran; Liu, Ying; Yang, Suijia; Chen, Yunjie; Lai, Luhua Journal of Medicinal Chemistry, 2011 , vol. 54, # 10 p. 3650 - 3660

Full Text: HTML

Citation Number: 22

Abstract

Dual target inhibitors against COX-2 and LTA4H were designed by adding functional groups from a marketed COX-2 inhibitor, Nimesulide, to an existing LTA4H inhibitor 1-(2-(4- phenoxyphenoxy) ethyl) pyrrolidine. A series of phenoxyphenyl pyrrolidine compounds were synthesized and tested for their inhibition activities using enzyme assays and human whole blood assay. Introduction of small electron withdrawing groups like NO2 and CF3 in the ...

Related Articles:

P (i-BuNCH 2 CH 2) 3 N: an efficient promoter for the microwave synthesis of diaryl ethers

[Raders, Steven M.; Verkade, John G. Tetrahedron Letters, 2008 , vol. 49, # 21 p. 3507 - 3511]

Iodo Derivatives of Phenyl Ether. II. Studies in Orientation

[Brewster; Choguill Journal of the American Chemical Society, 1939 , vol. 61, p. 2702]

Dual Nucleophilic Substitution Reactions of O, O??Diethyl 2, 4??dinitrophenyl Phosphate and Thionophosphate Triesters

[Aguayo, Raul; Arias, Felipe; Canete, Alvaro; Zuniga, Carolina; Castro, Enrique A.; Pavez, Paulina; Santos, Jose G. International Journal of Chemical Kinetics, 2013 , vol. 45, # 3 p. 202 - 211]

Dual Nucleophilic Substitution Reactions of O, O??Diethyl 2, 4??dinitrophenyl Phosphate and Thionophosphate Triesters

[Aguayo, Raul; Arias, Felipe; Canete, Alvaro; Zuniga, Carolina; Castro, Enrique A.; Pavez, Paulina; Santos, Jose G. International Journal of Chemical Kinetics, 2013 , vol. 45, # 3 p. 202 - 211]

Index of authors' names

[Borrows; Clayton; Hems Journal of the Chemical Society, 1949 , p. Spl. 185, 188]

More Articles...