One-pot synthesis of pharmacologically active diamines via rhodium-catalysed carbonylative hydroaminomethylation of heterocyclic allylic amines

T Rische, KS Mu, P Eilbracht

Index: Rische, Thorsten; Mueller, Kai-Sven; Eilbracht, Peter Tetrahedron, 1999 , vol. 55, # 32 p. 9801 - 9816

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Citation Number: 38

Abstract

Pharmacologically active derivatives of phenothiazine, iminodibenzyl, carbazole and pyrazole are prepared with high yields and chemoselectivity by the reaction of the correspondingN-allylic orN-methallylic compounds, primary or secondary amines, carbon monoxide and hydrogen in the presence of [Rh (cod) Cl] 2 as catalyst via a one pot hydroformylation-amine condensation-reduction sequence.