Synthesis and antiproliferative activity of substituted benzopyranoisoindoles: A new class of cytotoxic compounds

C Hadjipavlou, IK Kostakis, N Pouli, P Marakos…

Index: Hadjipavlou, Christiana; Kostakis, Ioannis K.; Pouli, Nicole; Marakos, Panagiotis; Pratsinis, Harris; Kletsas, Dimitris Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 18 p. 4822 - 4825

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Citation Number: 5

Abstract

A series of novel aminosubstituted benzopyranoisoindoles possessing structural analogy to an active nitracrine metabolite are reported. The compounds exhibited interesting cytotoxic activity against a panel of cell lines, which was maximized by the presence of both 1- dialkylaminoethyl and 3-nitro substituents.

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