Fluoronaphthyridines and-quinolones as antibacterial agents. 5. Synthesis and antimicrobial activity of chiral 1-tert-butyl-6-fluoro-7-substituted-naphthyridones

P Di Cesare, D Bouzard, M Essiz…

Index: Cesare, P. Di; Bouzard, D.; Essiz, M.; Jacquet, J. P.; Ledoussal, B.; et al. Journal of Medicinal Chemistry, 1992 , vol. 35, # 22 p. 4205 - 4213

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Citation Number: 29

Abstract

0.17 0.17 a Yields are given for the halogen exchange reaction and saponification. C, H, and N analysis were within &0. 4% of theoretical values, except as otherwise noted. ferred remarkable improvements in the Gram-positive (Staphylococci and Streptococci) antibacterial potency in vitro. Moreover, studies in our laboratorieslS2l involving the 1- position of the quinolones and naphthyridones have established that a tert-butyl moiety for ...