Synthesis of β-Amino Acids: 2-(1H-Benzotriazol-1-yl)-1, 1, 3, 3-tetramethyluronium Tetrafluoroborate (TBTU) for Activation of Fmoc-/Boc-/Z-α-Amino Acids

…, GR Vasanthakumar, VV Suresh Babu

Index: Patil, Basanagoud S.; Vasanthakumar, Ganga-Ramu; Suresh Babu Synthetic Communications, 2003 , vol. 33, # 18 p. 3089 - 3096

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Citation Number: 9

Abstract

Abstract A new and efficient method for the homologation of urethane protected α-amino acids to its β-homomers by the Arndt-Eistert method using TBTU as a coupling agent is described. Several Fmoc-/Boc-/Z-protected α-amino diazoketone derivatives have been obtained as crystalline solids in good yield. The method is found to be rapid and stereospecific.

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