Bulletin of the Korean Chemical Society

A convenient one-pot Biginelli reaction catalyzed by Y (OAc) 3: an improved protocol for the synthesis of 3, 4-dihydropyrimidin-2 (1H)-ones and their sulfur analogues

G Aridoss, YT Jeong

Index: Aridoss, Gopalakrishnan; Jeong, Yeon Tae Bulletin of the Korean Chemical Society, 2010 , vol. 31, # 4 p. 863 - 868

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Citation Number: 29

Abstract

Abstract Yttrium (III) acetate hydrate-catalyzed novel synthesis of 3, 4-dihydropyrimidin-2 (1H)-(thio) one derivatives was achieved through one-pot three-component condensation of diversified aldehydes,-ketoesters and urea or N-methylurea or thiourea with a molar ratio of 1: 1: 1.4. In comparison to the classical Biginelli approach, this catalytic method has the advantages of short reaction time and improved product yield.