Xenobiotica

Metabolic inactivation of 2-oxiranylmethyl 2-ethyl2, 5-dimethylhexanoate (C10GE) in skin, lung and liver of human, rat and mouse

PJ Boogaard, PA Van Elburg, KP De Kloe…

Index: Boogaard; Van Elburg; De Kloe; Watson; Van Sittert Xenobiotica, 1999 , vol. 29, # 10 p. 987 - 1006

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Citation Number: 9

Abstract

1. The inactivation of 2-oxiranylmethyl 2-ethyl-2, 5-dimethylhexanoate (C10GE), one of the most abundant isomers of the epoxy-resin Cardura® E-10 glycidyl ester, was studied in subcellular fractions of human, C3H mouse and F344 rat liver, lung and skin. 2. C10GE is chemically very stable and resistant to aqueous hydrolysis, but it was rapidly metabolized in both cytosolic and microsomal fractions of all organs by epoxide hydrolase (EH)-catalysed ...