Chemistry Letters

N, N, N', N'-Tetramethylchloroformamidinium chloride as an efficient condensation reagent for a novel esterification applicable to the macrolide synthesis.

T Fujisawa, T Mori, K Fukumoto, T Sato

Index: Fujisawa, Tamotsu; Mori, Toshiki; Fukumoto, Kazumasa; Sato, Toshio Chemistry Letters, 1982 , p. 1891 - 1894

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Citation Number: 10

Abstract

N, N, N′, N′-Tetramethylchloroformamidinium chloride, prepared easily from N, N, N′, N′-tetramethylurea and oxalyl chloride, is found to be an efficient condensation reagent for an esterification of carboxylic acids with alcohols under mild conditions in one-pot procedure, and the reagent is applied to the lactonization for macrolide synthesis from ω- hydroxycarboxylic acids.