Design, synthesis, and BK channel-opening activity of hexahydrodibenzazepinone derivatives

…, K Furukawa, H Tsuru, S Adachi-Akahane…

Index: Tashima, Toshihiko; Toriumi, Yoshimi; Mochizuki, Yumi; Nonomura, Taro; Nagaoka, Satoru; Furukawa, Katsuo; Tsuru, Hiromichi; Adachi-Akahane, Satomi; Ohwada, Tomohiko Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 23 p. 8014 - 8031

Full Text: HTML

Citation Number: 26

Abstract

In order to explore new scaffolds for large-conductance Ca2+-activated K+ channel (BK channel) openers, we carried out molecular design and synthesis on the basis of the following two concepts:(1) introduction of a heteroatom into the dehydroabietic acid (BK channel opener) skeleton would allow easier introduction of substituents.(2) Because of the fourfold symmetrical structure of BK channels, dimeric compounds in which two ...

Related Articles:

Atom-Economical Synthesis of Functionalized Cycloalkanes via Catalytic Redox Cycloisomerization of Propargyl Alcohols

[Trost, Barry M.; Breder, Alexander; Kai, Bao Organic Letters, 2012 , vol. 14, # 7 p. 1708 - 1711]

Ag-mediated reactions: Coupling and heterocyclization reactions

[Boaventura, Maria-Amelia; Drouin, Jacques Bulletin de la Societe Chimique de France, 1987 , # 6 p. 1015 - 1026]

Strong base-induced intramolecular cycloaddition of homophthalic anhydrides: an efficient synthesis of polycyclic peri-hydroxy aromatic compounds

[Kita, Yasuyuki; Okunaka, Ryuichi; Honda, Takao; Shindo, Miki; Taniguchi, Miyako; et al. Journal of Organic Chemistry, 1991 , vol. 56, # 1 p. 119 - 125]

More Articles...