A feasibility study on the synthesis of phenylephrine via ruthenium-catalyzed homogeneous asymmetric hydrogenation

JF McGarrity, A Zanotti-Gerosa

Index: Tetrahedron Asymmetry, , vol. 21, # 20 p. 2479 - 2486

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Citation Number: 11

Abstract

... Tetrahedron: Asymmetry. ... however, must operate at catalyst loadings as low as possible in order to be cost-effective, while retaining high stereoselectivity, volume, and time ... of KOH (5 equiv in the reactions reported in entry 23, 2.5 equiv in entry 22 and 1.5 equiv in entry 21). ...