Synthesis and anticancer activities of novel 3, 5-disubstituted-1, 2, 4-oxadiazoles

D Kumar, G Patel, EO Johnson, K Shah

Index: Kumar, Dalip; Patel, Gautam; Johnson, Emmanuel O.; Shah, Kavita Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 10 p. 2739 - 2741

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Citation Number: 52

Abstract

A series of 3, 5-disubstituted-1, 2, 4-oxadiazoles were synthesized and evaluated for their in vitro anti-proliferative activities against various cancer cell lines. Formation of 1, 2, 4- oxadiazole ring was accomplished by the reaction of amidoxime with carboxylic acids. The in vitro cytotoxic effects of 3, 5-disubstituted-1, 2, 4-oxadiazoles have been demonstrated across a wide array of tumor cell types and a few compounds exhibited specificity towards ...