Synthesis and in vitro antitumor activity of asperphenamate derivatives as autophagy inducer

…, C Zou, C Wang, J Gao, C Miao, E Ma, T Sun

Index: Yuan, Lei; Li, Yanchun; Zou, Chunyang; Wang, Chao; Gao, Jian; Miao, Caixia; Ma, Enlong; Sun, Tiemin Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 6 p. 2216 - 2220

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Citation Number: 8

Abstract

In an effort to improve the aqueous solubility and the antitumor activity of natural product asperphenamate, we have designed and synthesized three series of asperphenamate derivatives, including series I (simplifying molecular skeleton series), series II (introducing a hydroxyl group to A-phenyl ring series) and series III (disrupting molecular planarity series). All derivatives have displayed a significantly increased solubility compared with ...