Discovery of phosphoinositide 3-kinases (PI3K) p110β isoform inhibitor 4-[2-hydroxyethyl (1-naphthylmethyl) amino]-6-[(2S)-2-methylmorpholin-4-yl]-1H-pyrimidin-2- …

…, H von Wachenfeldt, SM Andersen, T Inghardt…

Index: Giordanetto, Fabrizio; Wallberg, Andreas; Ghosal, Saswati; Iliefski, Tommy; Cassel, Johan; Yuan, Zhong-Qing; Von Wachenfeldt, Henrik; Andersen, Soren M.; Inghardt, Tord; Tunek, Anders; Nylander, Sven Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 21 p. 6671 - 6676,6

Full Text: HTML

Citation Number: 10

Abstract

Structure-based evolution of the original fragment leads resulted in the identification of 4-[2- hydroxyethyl (1-naphthylmethyl) amino]-6-[(2S)-2-methylmorpholin-4-yl]-1H-pyrimidin-2- one,(S)-21, a potent, selective phosphoinositide 3-kinases (PI3K) p110β isoform inhibitor with favourable in vivo antiplatelet effect. Despite its antiplatelet action,(S)-21 did not significantly increase bleeding time in dogs. Additionally, due to its enhanced selectivity ...

Related Articles:

Stereochemistry of aziridine formation by reduction of oximes with lithium aluminum hydride on aralkyl alkyl ketoximes and their tosylates

[Kotera,K. et al. Tetrahedron, 1968 , vol. 24, p. 5677 - 5690]

Stereochemistry of aziridine formation by reduction of oximes with lithium aluminum hydride on aralkyl alkyl ketoximes and their tosylates

[Kotera,K. et al. Tetrahedron, 1968 , vol. 24, p. 5677 - 5690]

Stereochemistry of aziridine formation by reduction of oximes with lithium aluminum hydride on aralkyl alkyl ketoximes and their tosylates

[Kotera,K. et al. Tetrahedron, 1968 , vol. 24, p. 5677 - 5690]

A novel fluorescent chemosensor for Cu (II) in aqueous solution based on a β-aminobisphosphonate receptor

[Kamila, Sukanta; Callan, John F.; Mulrooney, Ray C.; Middleton, Moira Tetrahedron Letters, 2007 , vol. 48, # 44 p. 7756 - 7760]

More Articles...