Chemical and Pharmaceutical Bulletin

Toward General Access to the Aspidosperma-Type Terpenoid Indole Alkaloids: Synthesis of the Key 3, 3-Disubstituted Piperidones through Enantioselective …

Y Yasui, H Takeda, Y Takemoto

Index: Yasui, Yoshizumi; Takeda, Hiroshi; Takemoto, Yoshiji Chemical and Pharmaceutical Bulletin, 2008 , vol. 56, # 11 p. 1567 - 1574

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Citation Number: 12

Abstract

An enantioselective intramolecular Heck-type reaction of chloroformamides has been developed for the synthesis of 3, 3-disubstituted piperidones. The desired piperidone was formed in the presence of a palladium catalyst, an optically active phosphoramidite ligand, K 3 PO 4 and Ag 3 PO 4. The obtained piperidone was converted to epieburnamonine.

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