Synthesis of Compounds with Hypnotic Properties. II. Phenoxymethylhydantoins1, 2

WB Whitney, HR Henze

Index: Whitney; Henze Journal of the American Chemical Society, 1938 , vol. 60, p. 1148,1150

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Citation Number: 7

Abstract

Picrasmh-A solution of 1 g. of picrasmin in an acetylating mixture of 8 cc. of acetic anhydride and 0.25 g. of anhydrous sodium acetate was boiled for one and one-half hours. Most of the anhydride was then removed by distillation, and the resulting mass was treated with water. The product that separated soon crystallized and yielded 0.8 g. of material with a melting poing of 200-205'. The crude crystals were dissolved in boiling methanol and allowed to ...