Tetrahedron letters

New solid phase synthesis of oligodeoxythymidine phosphorodithioates by a modified HObt-method

AB Eldrup, J Felding, J Kehler, O Dahl

Index: Eldrup, Anne B.; Felding, Jakob; Kehler, Jan; Dahl, Otto Tetrahedron Letters, 1995 , vol. 36, # 34 p. 6127 - 6130

Full Text: HTML

Citation Number: 5

Abstract

Two new dithiophosphorylating reagents 2a, b have been prepared and shown to give nucleoside monomers 3a, b with reactivities suitable for solid phase synthesis. An octamer and a nonamer deoxythymidine phosphorodithioate were prepared on a TentaGel support with good coupling efficiencies. The products after deblocking are free from phosphorothioate contaminations (detection limit 0.5%).

Related Articles:

Synthesis and in vitro antibacterial activity of 5-halogenomethylsulfonyl-benzimidazole and benzotriazole derivatives

[Ochal, Zbigniew; Bretner, Maria; Wolinowska, Renata; Tyski, Stefan Medicinal Chemistry, 2013 , vol. 9, # 8 p. 1129 - 1136]

Measurement of carbonyl compounds as the 2, 4-dinitrophenylhydrazonate anion. Reaction mechanism and an automated measurement system

[Dasgupta, Purnendu K.; Zhang, Genfa; Schulze, Shawn; Marx, John N. Analytical Chemistry, 1994 , vol. 66, # 13 p. 1965 - 1970]

Spectrophotometric Determination of pK (a)'s of 1-Hydroxybenzotriazole and Oxime Derivatives in 95% Acetonitrile-Water

[Fathalla, Magda Fouad; Khattab, Sherine Nabil Journal of the Chemical Society of Pakistan, 2011 , vol. 33, # 3 p. 324 - 332]

Synthesis and in vitro antibacterial activity of 5-halogenomethylsulfonyl-benzimidazole and benzotriazole derivatives

[Ochal, Zbigniew; Bretner, Maria; Wolinowska, Renata; Tyski, Stefan Medicinal Chemistry, 2013 , vol. 9, # 8 p. 1129 - 1136]

Synthesis and Aminolysis of N, N-Diethyl Carbamic Ester of HOBt Derivatives

[Khattab, Sherine Nabil; Hassan, Seham Yassin; Hamed, Ezzat Awad; Albericio, Fernando; Ayman, El-Faham Bulletin of the Korean Chemical Society, 2010 , vol. 31, # 1 p. 75 - 81]

More Articles...