Synthesis of Compounds Related to Thymine. III. Chlorosulfonation of Uracil

RR Herr, T Enkoji, TJ Bardos

Index: Herr et al. Journal of the American Chemical Society, 1956 , vol. 78, p. 401

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Citation Number: 6

Abstract

It has been reported recently'that 5-mercaptouracil and some of its derivatives are competitive antagonists of thymine. These compounds originally were synthesized by us from 5-aminouracil by way of the diazonium salt. 2 In the course of an exploration of alternative routes of synthesis which might be more applicable to the preparation of larger quantities, the synthesis of 5-mercaptouracil by way of 5-uracilsulfonyl chloride was ...