Thieno [3, 2-d] pyrimidin-4 (3H)-one derivatives as PDK1 inhibitors discovered by fragment-based screening

ACH Lee, PM Ramanujulu, A Poulsen…

Index: Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 12 p. 4023 - 4027

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Abstract

... Bioorganic & Medicinal Chemistry Letters. ... Compound, Chemical structure, MW, LE a, PDK1 IC 50 (μM) 13. ... potency and high ligand efficiency prompted us to select the thieno[3,2-d]pyrimidin- 4(3H)-ones 4 and 5 as our first-choice start points for medicinal chemistry and we now ...

Thieno [3, 2-d] pyrimidin-4 (3H)-one derivatives as PDK1 inhibitors discovered by fragment-based screening

[Lee, Angeline C.-H.; Ramanujulu, Pondy Murugappan; Poulsen, Anders; Williams, Meredith; Blanchard, Stephanie; Ma, Diana M.; Bonday, Zahid; Goh, Kay Lin; Goh, Kee Chuan; Goh, Miah Kiat; Wood, Jeanette; Dymock, Brian W. Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 12 p. 4023 - 4027]

Thieno [3, 2-d] pyrimidin-4 (3H)-one derivatives as PDK1 inhibitors discovered by fragment-based screening

Abstract

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